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D C Whitcomb Selected Research

Hereditary pancreatitis

5/2006A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance.
2/2002Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis.
8/2001Lessons from hereditary pancreatitis.
5/2001Motivations and concerns of patients with access to genetic testing for hereditary pancreatitis.
1/2001SPINK1 mutations are associated with multiple phenotypes.
1/2001Hereditary pancreatitis: a model for understanding the genetic basis of acute and chronic pancreatitis.
1/2001Hereditary pancreatitis in North America: the Pittsburgh-Midwest Multi-Center Pancreatic Study Group Study.
9/2000SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.

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D C Whitcomb Research Topics

Disease

9Chronic Pancreatitis
05/2011 - 09/2000
8Pancreatitis
03/2020 - 09/2000
8Hereditary pancreatitis
05/2006 - 09/2000
4Inflammation (Inflammations)
10/2013 - 05/2006
2Body Weight (Weight, Body)
11/2005 - 07/2004
2Obesity
11/2005 - 07/2004
2Pancreatic Diseases (Pancreatic Disease)
01/2001 - 01/2001
2Wounds and Injuries (Trauma)
11/2000 - 03/2000
1Pain (Aches)
03/2020
1Intractable Pain
03/2020
1Pancreatic Neoplasms (Pancreatic Cancer)
03/2020
1Necrosis
10/2013
1Acute Necrotizing Pancreatitis
10/2013
1Weight Loss (Weight Reduction)
05/2011
1Exocrine Pancreatic Insufficiency
05/2011
1Weight Gain
05/2011
1Fibrosis (Cirrhosis)
07/2007
1Type 2 Diabetes Mellitus (MODY)
06/2005
1Autolysis
02/2002
1Cicatrix (Scar)
03/2000

Drug/Important Bio-Agent (IBA)

6Kazal Pancreatic Trypsin InhibitorIBA
05/2006 - 09/2000
5TrypsinogenIBA
05/2006 - 01/2001
3TrypsinIBA
08/2001 - 09/2000
2Interleukin-6 (Interleukin 6)IBA
06/2010 - 09/2000
2Messenger RNA (mRNA)IBA
05/2006 - 11/2000
2Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
06/2005 - 01/2001
2DNA (Deoxyribonucleic Acid)IBA
05/2001 - 03/2000
2Complementary DNA (cDNA)IBA
11/2000 - 03/2000
1Caspase 1 (ICE Protease)IBA
10/2013
1HMGB1 Protein (HMG1)IBA
10/2013
1InflammasomesIBA
10/2013
1Pancrelipase (Creon)FDA Link
05/2011
1AntioxidantsIBA
01/2011
1Analgesics (Analgesic Drugs)IBA
01/2011
1Octreotide (Sandostatin)FDA LinkGeneric
01/2011
1VitaminsIBA
01/2011
1ResistinIBA
06/2010
1Nicotinamide PhosphoribosyltransferaseIBA
06/2010
1AdipokinesIBA
06/2010
1LeptinIBA
06/2010
1AdiponectinIBA
06/2010
1Biomarkers (Surrogate Marker)IBA
07/2007
1Acute-Phase Proteins (Acute-Phase Protein)IBA
05/2006
1MelanocortinsIBA
11/2005
1Peptide YYIBA
11/2005
1Neuropeptide YIBA
11/2005
1Peptide Hormones (Polypeptide Hormones)IBA
07/2004
1Arginine (L-Arginine)FDA Link
02/2002
1Serine Proteases (Serine Protease)IBA
08/2001
1ProstaglandinsIBA
11/2000
1EP4 Subtype Prostaglandin E ReceptorsIBA
11/2000
1C-Reactive ProteinIBA
09/2000
1Chaperonin Containing TCP-1IBA
03/2000
1GelsIBA
03/2000
1ChaperoninsIBA
03/2000

Therapy/Procedure

4Therapeutics
01/2011 - 02/2001
2Enzyme Replacement Therapy
05/2011 - 01/2011
1Pancreaticojejunostomy
03/2020
1Pancreaticoduodenectomy
03/2020
1Role Playing (Playing, Role)
08/2001